报告题目: Highly Active Supported Catalysts

报告人: Yoichi M. A. Yamada (山田 阳一)教授

报告时间: 2019年10月24日，星期四14:30

报告地点:仲英楼B253

报告摘要

It is important to develop metalloprotein-inspired polymer-supported metal catalysts, ensuring catalytic activity, stability and reusability for safe, non-toxic, sustainable chemistry, and green organic synthesis. We have reported convoluted polymeric metal catalysts for organic transformation reactions, where a soluble linear polymer having multiple ligand groups is cross-linked with transition metals via coordinative complexation. Here, we report development of a highly active and reusable polymeric imidazole palladium catalyst MPPI-Pd. By using 0.28 mol ppm (0.000028 mol %) to 0.1 mol % of MPPI-Pd, the allylic arylation, the Suzuki-Miyaura reaction, and the Mizoroki-Heck reaction proceeded smoothly to give the corresponding coupling products in high yield. MPPI-Pd was reused without loss of catalytic activity.[1] This methodology was also applied to preparation of highly active copper catalysts[2] and others.[3,4]

参考文献

[1] (a) S. M. Sarkar, Y. Uozumi, Y. M. A. Yamada,Angew. Chem., Int. Ed.2011,50, 9437-9441; (b) Y. M. A. Yamada, S. M. Sarkar, Y. Uozumi,J. Am. Chem. Soc.2012,134, 9285-9290; (c) T. Sato, A. Ohno, S. M. Sarkar, Y. M. A. Yamada, Y. Uozumi,ChemCatChem2015,7, 2141-2148. d) R. Hudson, H. R. Zhang, A. LoTemplio, G. Benedetto, G. Hamasaka, Y. M. A. Yamada, J. L. Katz, Y. Uozumi,Chem. Commun.,2018,54, 2878-2881.

[2] (a) Y. M. A. Yamada, A. Ohno, T. Sato, Y. Uozumi,Chem Eur. J.2015,21, 17269-17273; (b) Y. M. A. Yamada, H. Yoshida, A. Ohno, T. Sato, T. Mase, Y. Uozumi,Heterocycles2017,95, 715-721; (c) H. Hu, A. Ohno, T. Sato, T. Mase, Y. Uozumi, Y. M. A. Yamada,Org. Proc Res. Dev.2019,23, 493-498.

[3] R. Hudson, G. Hamasaka, T. Osako, Y. M. A. Yamada, C.-J. Li, Y. Uozumi, A. Moores,Green Chem.2013,15, 2141-2148.

[4] T. S. Symeonidis, A. Athanasoulis, R. Ishii, Y. Uozumi, Y. M. A. Yamada, I. N. Lykakis,ChemPhotoChem2017,1. 479-484.

报告人简介：

研究领域 非均相催化·光催化·绿色可持续化学·药物化学

教育经历

1994东京大学 学士

1999东京大学 博士（药学）导师：Masakatsu Shibasaki（柴崎正胜教授)

1999帝京大学 助理教授, Shiro Ikegami研究组

2003美国Scripps研究所  研究员，K.C. Nicolaou研究组

2003日本分子科学研究所 助教，Yasuhiro Uozumi研究组

2007日本理化学研究所（RIKEN) CSRS研究中心Deputy Team Leader, Yasuhiro Uozumi研究组

2018日本理化学研究所（RIKEN) CSRS研究中心Team Leader

2018埼玉大学 客座教授（兼任）